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June 2016   Comments

Combined effects of depression and metabolic dysregulation

Depression may compound the risk of developing type 2 diabetes in people with early warning signs of metabolic disease, such as obesity, high blood pressure and high cholesterol levels, according to researchers from Montreal and Calgary. In a study published in Molecular Psychiatry, the investigators divided 2,525 participants in Quebec, age 40 to 69, into four groups: those with three or more metabolic risk factors (a condition termed metabolic dysregulation) and depression; those with depression but not metabolic dysregulation; those with metabolic dysregulation but not depression; and those with neither condition.

The investigators discovered that the participants with depression alone were not at significantly greater risk of developing diabetes than those in the control group. Compared with the control group, the group with metabolic dysregulation but not depression was about four times as likely to develop diabetes and the group with both depression and metabolic dysregulation was more than six times as likely to develop the disease. The analysis showed that the combined effect of depression and metabolic dysregulation was greater than the sum of the individual effects of these two conditions.


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