Tricking the immune system to fight colon cancer

October 2015   Comments

A major shift in thinking has Princess Margaret Cancer Centre researchers mimicking a virus and potentially triggering an immune response to fight colorectal cancer like an infection. Their work could lead to a druggable target against colorectal cancer stem cells. In the laboratory, a low-dose of decitabine targeted the cancer stem cells by inducing viral mimicry. This chemotherapy drug could be combined with immune therapy to advance personalized cancer care by boosting an individual’s natural immune system. The next step is to start clinical trials to see if this discovery will result in durable cures.

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