Diabetes “dimmer switch” identified

November 2015   Comments

Researchers examining pancreatic islet cells from 99 human organ donors have identified a new molecular pathway that manages the amount of insulin produced by those cells. Published in the Journal of Clinical Investigation, the research indicates that this “dimmer switch,” which adjusts how much insulin is secreted when blood sugar rises, appears to be lost in type 2 diabetes. While it may be possible to fix this mechanism on a molecular level, the lead author, from the University of Alberta, says it could take decades to translate this work into clinical use.

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