Genetic engineering preserves breast tissue in mice

May 2015   Comments

Researchers at the University of Toronto have found a way to keep breast tissue young in genetically modified mice. The mice were engineered to lack certain proteins called tissue inhibitors of metalloproteinases (TIMPs). Normally, TIMPs play a role in directing the formation and breakdown of tissue. The researchers found that when TIMP1 and TIMP3 were absent, the mice produced more stem cells. The stem cells did not decrease in number as the mice aged, and their breast tissue remained youthful and healthy. The findings may have implications for breast cancer prevention.

comments powered by Disqus